Palladium-catalyzed enantioselective [5 + 4] annulation of <i>ortho</i>-quinone methides and vinylethylene carbonates
Chao Xia, Dong‐Chao Wang, Gui‐Rong Qu, Hai‐Ming Guo
Abstract
Highly enantioselective [5 + 4] annulations of <italic>ortho</italic>-quinone methides with vinylethylene carbonates are enabled by asymmetric palladium catalysis for the synthesis of chiral nine-membered benzo-heterocycles.
Topics & Concepts
Enantioselective synthesisAnnulationChemistryPalladiumCatalysisQuinoneOrganic chemistryCombinatorial chemistryMedicinal chemistryStereochemistrySynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions