Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus
Honghao Huang, Peng Wan, Xinyue Luo, Yixing Lu, Xiaoshen Li, Wenguang Xiong, Zhenling Zeng
Abstract
. However, no research has evaluated the effects of diverse mutations discovered in TRSA in MepA. This study demonstrates that the mutations in MepA confer resistance to tigecycline without overexpression and provides genotypic references for identifying TRSA. Although tigecycline resistance-associated mutations in MepA identified in this study have not been observed in clinical isolates, the mechanism should be explored given that S. aureus strains are prevalent in the environment. Measures should be implemented to contain TRSA within the time window before tigecycline resistance-associated mutations in MepA are prevalent.
Topics & Concepts
TigecyclineEffluxMutantStaphylococcus aureusBiologyMicrobiologyMinocyclineMultiple drug resistanceDrug resistanceGeneAntibioticsBiochemistryGeneticsBacteriaAntibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility Testing