Canine atopic dermatitis attenuated by mesenchymal stem cells
Fernanda de Oliveira Ramos, Patrícia Furtado Malard, Hilana dos Santos Sena Brunel, Giane Regina Paludo, Márcio Botelho de Castro, Paulo Henrique Sampaio da Silva, André Rodrigues da Cunha Barreto Vianna, Eduardo Lima
Abstract
OBJECTIVE: To evaluate the use of mesenchymal stem cells (MSCs) in the attenuation of canine atopic dermatitis (AD). MATERIALS AND METHODS: /kg bodyweight of MSC's in all groups by the intravenous route with intervals of applications of 21 days. The degree of pruritus was evaluated by examining the visual analog scale, the CADESI-4, the histopathology of the skin, hematological and biochemical parameters, the pyogenic effect of MSCs, and the thickness of the epidermis. RESULTS: There was a significant difference in the reduction of epidermal thickness in the moderate and severe groups. Hematological, biochemical, and body temperature parameters remained within normal limits for the species with no side effects. CONCLUSION: MSCs attenuated the clinical signs of AD.