Regulation of bone mass in endocrine diseases including diabetes
Claire Higham, Bo Abrahamsen
Abstract
Hormonal regulation plays a key role in determining bone mass in humans. Both skeletal growth and bone loss in health and disease is critically controlled by endocrine factors and low bone mass is a feature of both excess and deficiency of a broad range of hormones. This article explores the impact of diabetes and thyroid, parathyroid, sex steroid and growth hormone disorders on bone mass and fracture risk. Evidence for current management strategies is provided along with suggested practice points and gaps in knowledge for future research.
Topics & Concepts
Endocrine systemHormoneDiabetes mellitusBone massBone healthMedicineEndocrinologyParathyroid hormonePeak bone massInternal medicineThyroidBone remodelingDiseaseOsteoporosisBioinformaticsPhysiologyBone mineralBiologyCalciumBone health and osteoporosis researchGrowth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and Cancer