Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning <i>via</i> Activating the AC3/PKA/HSL Pathway
Xifen Zheng, Wenting Huang, Qianbei Li, Yun Chen, Linyan Wu, Yifan Dong, Xinyue Huang, Xiaojing He, Zihao Ou, Yongzheng Peng
Abstract
the AC3/PKA/HSL pathway, phosphorylating HSL at Ser 660. The experiments illustrated here identify the specific molecules and functional mechanisms of Akk. Therapeutic approaches with Amuc_1100 derived from Akk may help alleviate obesity and metabolic disorders.
Topics & Concepts
Akkermansia muciniphilaLipolysisLipid metabolismBiochemistryLipid dropletMetabolismChemistryBiologyAdipose tissueGut floraDiet and metabolism studiesPancreatic function and diabetesDiet, Metabolism, and Disease