Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-κB signaling pathway
Long Huo, Qian Chen, Sailei Jia, Yuli Zhang, Lihui Wang, Xian Li, Zan Li, Boyun Sun, Jingyi Shan, Jiang Lin, Lili Yang, Hua Sui
Abstract
The gut microbiota contributes to host physiology through the production of a myriad of metabolites. Owing to the high degree of cross talk both within and between biological kingdoms, metabolite-focused research has identified multiple actionable microbial targets that are relevant for host health. In this study, we demonstrated that the microbiota consumption of succinate can alleviate DSS-induced UC in mice responses by modulating glycolytic metabolism through the SUCNR1/NF-κB signaling pathway.
Topics & Concepts
Ulcerative colitisGlycolysisMicrobiomeSignal transductionNF-κBCell biologyGut microbiomeColitisChemistryCancer researchBiologyBiochemistryImmunologyMetabolismMedicineBioinformaticsInternal medicineDiseaseGut microbiota and healthInflammatory Bowel DiseasePharmacological Effects of Natural Compounds