Indirect electrochemical reductive cyclization of<i>o</i>-halophenylacrylamides mediated by phenanthrene
Xue‐Qi Zhou, Pei‐Bo Chen, Qiang Xia, Ting‐Kai Xiong, Xuejun Li, Ying‐Ming Pan, Mu‐Xue He, Ying Liang
Abstract
We report a synthesis method for the selective 6- endo cyclization of o -phenylacrylamides to obtain 3,4-dihydroquinolinones via aryl anions formed by two-electron reduction under electrochemistry using phenanthrene as the reduction mediator.
Topics & Concepts
ChemistryPhenanthreneElectrochemistryReduction (mathematics)ArylCombinatorial chemistryMedicinal chemistryOrganic chemistryElectrodePhysical chemistryGeometryMathematicsAlkylRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques