Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice
Haowen Xu, Weifeng Li, Shanshan Hong, Jingjing Shao, Jiahao Chen, Nipon Chattipakorn, Di Wu, Wu Luo, Guang Liang
Topics & Concepts
InflammasomePharmacologyIC50Natural productInflammationChemistryKnockout mouseMedicineBiochemistryIn vitroReceptorImmunologyInflammasome and immune disordersCholesterol and Lipid MetabolismSphingolipid Metabolism and Signaling