Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Àvila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Köster, Fernando Salgado-Polo, Sander de Kivit, Telma Lança, Antonio Mazzocca, Zoë Johnson, John B.A.G. Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar
Abstract
T cell infiltration to impede anti-tumor immunity, suggesting new therapeutic opportunities.
Topics & Concepts
AutotaxinTumor microenvironmentLysophosphatidic acidCancer researchCytotoxic T cellCD8T cellBiologyCell biologyTumor progressionImmune systemCancer immunotherapyMelanomaImmunotherapyImmunologyReceptorCancerBiochemistryIn vitroGeneticsSphingolipid Metabolism and SignalingEndoplasmic Reticulum Stress and DiseasePhagocytosis and Immune Regulation