Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate
Cecília Pessoa Rodrigues, Josip S. Herman, Benjamin Herquel, Claudia Isabelle Keller Valsecchi, Thomas Stehlé, Dominic Grün, Asifa Akhtar
Abstract
expression act as a rheostat for the feedforward transcription factor network that safeguards progression along the erythroid fate.
Topics & Concepts
BiologyCell biologyChromatinTranscription factorChromatin immunoprecipitationCell fate determinationRUNX1H3K4me3GATA1HistoneHaematopoiesisStem cellGeneticsGene expressionGenePromoterEpigenetics and DNA MethylationAcute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomics