Sulphur ylide-mediated cyclopropanation and subsequent spirocyclopropane rearrangement reactions
Qing‐Song Dai, Jun‐Long Li, Qiwei Wang, Si-Lin Yang, Ying-Mao Tao, Mei-Hao He, Qing‐Zhu Li, Bo Han, Xiang Zhang
Abstract
A formal (2 + 1) annulation and three-component (1 + 1 + 1) cascade cyclisation via sulphur ylide cyclopropanation under mild conditions is described, with the spiro-cyclopropyl iminoindoline moiety transformed into pyrrolo[3,4- c ]quinoline through a novel rearrangement process.
Topics & Concepts
CyclopropanationYlideAnnulationChemistryMoietySulfurQuinolineCascadeStereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisChromatographyCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis