Substituent-controlled chemoselective synthesis of multi-substituted pyridones <i>via</i> a one-pot three-component cascade reaction
Shitao Liu, Jisen Li, Jun-Jie Lin, Fujun Liu, Teng Liu, Chao Huang
Abstract
under solvent-free conditions has been developed. The substituent-controlled chemoselective cycloaddition process involved steps including a Michael addition/ethanol elimination/intermolecular cyclization sequence utilizing anilines, diethyl acetylenedicarboxylate, and diethyl ethoxymethylenemalonate. In doing so, various 2-pyridone and 4-pyridone species (41 examples) could be obtained in good to excellent yields.
Topics & Concepts
ChemistrySubstituentCascadeComponent (thermodynamics)Combinatorial chemistryCascade reactionStereochemistryOrganic chemistryCatalysisChromatographyThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of heterocyclic compounds