Semi-synthesis, α-amylase inhibition, and kinetic and molecular docking studies of arylidene-based sesquiterpene coumarins isolated from <i>Ferula tunetana</i> Pomel ex Batt
Wiem Baccari, Ilyes Saidi, Insaf Filali, Mansour Znati, Houda Lazrag, Moncef Tounsi, Axel Marchal, Pierre Waffo‐Téguo, Hichem Ben Jannet
Abstract
Despite all the significant progress made to enhance the efficacy of the existing bank of drugs used to manage and cure type II diabetes mellitus, there is still a need to explore novel, effective bioactive compounds with fewer side effects.
Topics & Concepts
CoumarinChemistrySesquiterpeneDocking (animal)StereochemistryAcarboseEnzymeAmylaseIC50ArylIn silicoCombinatorial chemistryIn vitroOrganic chemistryBiochemistryAlkylNursingGeneMedicinePlant chemical constituents analysisSynthesis and biological activityTraditional and Medicinal Uses of Annonaceae