Multisystem Inflammatory Syndrome in Children in the United States
Leora R Feldstein, Erica B Rose, Adrienne G. Randolph
Abstract
23 issue) present case series of the multisystem inflammatory syndrome in children (MIS-C; also called the pediatric inflammatory multisystem syndrome); Levin 3 provides commentary. To address the burden of MIS-C in France, a nationwide surveillance program was launched on April 30, 2020, by Sant Publique France (the French national public health agency) and French pediatric scientific societies. Results in the first 108 cases have been published; similar to the cases reported by Feldstein et al. and Dufort et al., these results showed a median patient age of 8 years, a temporospatial distribution that is evocative of a link to the outbreak of coronavirus disease 2019 , and an overlap of macrophage activation syndrome, serositis, Kawasaki's disease-like features, and myocarditis in half the cases. 4 As of June 21, 2020, a total of 195 cases (i.e., hospitalizations) had been reported, with 138 classified as being associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to our case definition (Fig. These updated surveillance data highlight the transient nature of MIS-C and suggest that in the absence of a second wave of Covid-19, new cases of MIS-C are expected to remain extremely rare and sporadic. This sequence is highly suggestive of a postinfectious disease for which adaptive immunity might be crucial in the pathogenesis.