Synthesis and Antimicrobial, Antiplatelet, and Anticoagulant Activities of New Isatin Deivatives Containing a Hetero-Fused Imidazole Fragment
А. В. Богданов, Aisylu R. Sirazieva, Alexandra D. Voloshina, Тимер Айратович Абзалилов, А. В. Самородов, В. Ф. Миронов
Abstract
A series of isatin derivatives containing an adenine or theophylline fragment have been synthesized. The corresponding N′-[2-(trimethylammonio)acetyl] and N′-(2-pyridinioacetyl) hydrazones have been found to exhibit neither cytotoxicity nor hemotoxicity. Quaternary salts based on adenine derivatives of 5-methyl- and 5-ethylisatins showed the highest antiplatelet activity which exceeded the activity of acetylsalicylic acid by a factor of 1.5.
Topics & Concepts
ChemistryIsatinImidazoleTheophyllineAntimicrobialCytotoxicityAntibacterial activityStereochemistryOrganic chemistryBiochemistryPharmacologyBacteriaIn vitroMedicineGeneticsBiologySynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis and Reactivity of Heterocycles