Electrochemically driven [4+2] benzannulation: synthesis of polycyclic (hetero)aromatic compounds
Ke Liu, Pengcheng Zhou, Yingli Xu, Zhiqi Yang, Dong Wang
Abstract
A green and economical electrochemical protocol has been developed to synthesize polycyclic (hetero)aromatic compounds by the [4+2] benzannulation of biaryldiazonium salts with alkynes. This protocol features a broad substrate scope. Instead of requiring diazonium reagents, these reactions can begin from anilines and can be carried out in one pot. Moreover, the readily accessible scale-up synthesis achieved by using an electrochemical flow cell demonstrates the synthetic potential of this protocol.
Topics & Concepts
ElectrochemistryReagentCombinatorial chemistrySubstrate (aquarium)ChemistryProtocol (science)Organic chemistryElectrodeOceanographyMedicineGeologyPhysical chemistryPathologyAlternative medicineRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods