Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases
Junqiu Zhai, Yu-e Wang, Xiangping Zhou, Yan Ma, Shixia Guan
Abstract
assessments demonstrated that uniform-sized microspheres generated by the microfluidic process sustainably released ASM throughout 40-days, showing low burst release and significantly improved bioavailability. The results suggest that ASM-PLGA microspheres prepared by the microfluidic method provide an efficient strategy to enhance the drug exposure of ASM as the treatment of chronic neuropsychiatric diseases. It is also evident that this microfluidic strategy has the potential to construct with other drugs, establishing long-acting formulations.
Topics & Concepts
BioavailabilityPLGAGlycolic acidAsenapineMaterials scienceMicrospherePharmacologyLactic acidNanotechnologyMedicineSchizophrenia (object-oriented programming)Chemical engineeringNanoparticleAntipsychoticGeneticsBacteriaPsychiatryBiologyEngineeringAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAdvancements in Transdermal Drug Delivery