Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2<i>H</i>-pyrrol-2-ones <i>via</i> base-assisted cyclization of 3-cyanoketones
Nicolai A. Aksenov, Дмитрий А. Аксенов, Igor A. Kurenkov, А. В. Аксенов, Антон А. Скоморохов, Lidiya A. Prityko, Michael Rubin
Abstract
The highly efficient oxidative cyclization of 1,3-diarylsubstituted 3-cyanoketones yielded 5-hydroxy-1,5-dihydro-2<italic>H</italic>-pyrrol-2-ones.
Topics & Concepts
Base (topology)ChemistryMedicinal chemistryCombinatorial chemistryMathematicsMathematical analysisSynthesis and Characterization of PyrrolesSynthesis and Reactivity of HeterocyclesSynthesis and Reactions of Organic Compounds