Zeaxanthin ameliorates obesity by activating the β3-adrenergic receptor to stimulate inguinal fat thermogenesis and modulating the gut microbiota
Jiahan Xie, Meihong Liu, Huimin Liu, Zhibo Jin, Fengtao Guan, Sitong Ge, Jie Yan, Mingzhu Zheng, Dan Cai, Jingsheng Liu
Abstract
, which were associated with the thermogenesis- and obesity-associated indices by Spearman's correlation analysis. Functional analysis of the gut microbiota indicated that ZEA treatment significantly enriched the lipid metabolism pathways. These results demonstrate that ZEA is a promising multi-target functional food for the treatment of obesity by activating β3-AR to stimulate iWAT thermogenesis, and modulating the gut microbiota.
Topics & Concepts
ThermogenesisEndocrinologyInternal medicineGut floraBiologyWhite adipose tissueAdipose tissuePRDM16AdipocyteThermogeninLeptinObesityBiochemistryMedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses