A role for intestinal alkaline phosphatase in preventing liver fibrosis
Yang Liu, Paul Cavallaro, Byeong–Moo Kim, Tao Liu, Hongyan Wang, Florian Kühn, Fatemeh Adiliaghdam, Enyu Liu, Robin Vasan, Ehsan Samarbafzadeh, M Farber, Junhui Li, Meng Xu, Vidisha Mohad, Michael Y. Choi, Richard A. Hodin
Abstract
Endogenous IAP is decreased during liver fibrosis, perhaps contributing to the gut barrier dysfunction and worsening fibrosis. Oral IAP protects the gut barrier and further prevents the development of liver fibrosis via a TLR4-mediated mechanism.
Topics & Concepts
Alkaline phosphataseFibrosisLiver fibrosisChemistryPathologyCancer researchMedicineInternal medicineBiochemistryEnzymeAlkaline Phosphatase Research StudiesLiver Disease Diagnosis and TreatmentPancreatitis Pathology and Treatment