A food web bioaccumulation model for the accumulation of per- and polyfluoroalkyl substances (PFAS) in fish: how important is renal elimination?
Jennifer Sun, Barry C. Kelly, Frank A. P. C. Gobas, Elsie M. Sunderland
Abstract
≥ 8 PFAS is primarily driven by phospholipid partitioning, and that renal elimination is negligible for these compounds. However, specific protein binding mechanisms are important for reproducing the observed tissue concentrations of many shorter-chain PFAAs, including protein transporter-mediated renal elimination. Additional data on protein-binding and membrane transport mechanisms for PFAS are needed to better understand the biological behavior of shorter-chain PFAAs and their alternatives.
Topics & Concepts
BioaccumulationEnvironmental chemistryChemistryFood chainPollutantFish <Actinopterygii>Food webEcologyOrganic chemistryBiologyFisheryEcosystemPer- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactAtmospheric chemistry and aerosols