Perspectives on the Treatment of Malignant Pleural Mesothelioma
Sam M. Janes, Doraid Alrifai, Dean A. Fennell
Abstract
Most mesotheliomas originate in the pleura and are due to asbestos exposure. The incidence is decreasing somewhat with asbestos remediation, but mortality remains high in part because of late diagnosis and treatment resistance. Pemetrexed–cisplatin and immune checkpoint inhibitors modestly extend survival.
Topics & Concepts
PemetrexedMedicineMesotheliomaAsbestosCisplatinOncologyIncidence (geometry)Pleural diseaseInternal medicineChemotherapyPathologyLungRespiratory diseaseOpticsMetallurgyMaterials sciencePhysicsOccupational and environmental lung diseasesPleural and Pulmonary DiseasesMedical Imaging and Pathology Studies