Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin
Chenhong Guo, Ting Cao, Long Tai Zheng, John L. Waddington, Xue-chu Zhen
Topics & Concepts
Conditional gene knockoutAgonistPharmacologySubstantia nigraMPTPNeuroprotectionDopamineDicerTamoxifenKnockout mouseSigma-1 receptorNeuroscienceMedicineDopamine receptorReceptorBiologyInternal medicineDopaminergicPhenotypeBiochemistrySmall interfering RNACancerGeneBreast cancerTransfectionPharmacological Receptor Mechanisms and EffectsNeuropeptides and Animal PhysiologyPain Mechanisms and Treatments