Non-canonical lipoproteins with programmable assembly and architecture
Md. Shahadat Hossain, Corina Maller, Yinghui Dai, Shikha Nangia, Davoud Mozhdehi
Abstract
The substrate promiscuity of an acyltransferase is leveraged to synthesize artificial lipoproteins bearing a non-canonical PTM (ncPTM). The non-canonical functionality of these lipoproteins results in a distinctive hysteretic assembly-absent from the canonical lipoproteins-and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity. This study demonstrates the promise of expanding the repertoire of PTMs for the development of nanomaterials with a unique assembly and function.
Topics & Concepts
Non canonicalFunction (biology)ChemistrySubstrate (aquarium)NanotechnologyComputer scienceMaterials scienceBiologyCell biologyEcologySupramolecular Self-Assembly in MaterialsAdvanced biosensing and bioanalysis techniquesConnective tissue disorders research