MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma
Babak Otoukesh, Mehdi Abbasi, Habib-o-lah Gorgani, Hossein Farahini, Mehdi Moghtadaei, Bahram Boddouhi, Peyman Kaghazian, Shayan Hosseinzadeh, Atefe Alaee
Abstract
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
Topics & Concepts
microRNAOsteosarcomaPI3K/AKT/mTOR pathwaySuppressorCancer researchBiologyBioinformaticsMetastasisComputational biologyProtein kinase BPhenotypeApoptosisMedicineCancerGeneGeneticsMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research