A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy
Yuping Zhou, Weikang Xia, Chuang Liu, S. Ye, Lei Wang, Ruiyuan Liu
Abstract
further validated the efficacy of cancer cell ablation and significant inhibition of tumor growth. Moreover, the immunofluorescence staining results and blood biochemical parameters after treatment proved the bio-safety of TPA-2PI. The dual-targeted TPA-2PI can serve as a desirable photosensitizer for efficient cancer treatment, and this work sheds light on the development of biological substrate and organelle multi-targeted photosensitizers for future biological applications.
Topics & Concepts
PhotosensitizerPhotodynamic therapyChemistryBiophysicsIn vivoMitochondrionCancer cellFluorescencePhotochemistryBiochemistryCancerMedicineBiologyOpticsInternal medicinePhysicsBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced biosensing and bioanalysis techniques