Multi-target antibacterial mechanism of ruthenium polypyridine complexes with anthraquinone groups against<i>Staphylococcus aureus</i>
Li Jiang, Yuanyuan Ma, Yiman Chen, Mengcheng Cai, Zhixing Wu, Yanshi Xiong, Xuemin Duan, Xiangwen Liao, Jintao Wang
Abstract
was comparable to that of vancomycin. Mechanism exploration results showed that the antibacterial behavior is probably related with targeting of the bacterial cell membrane and inhibiting topoisomerase I.
Topics & Concepts
ChemistryRutheniumAntibacterial activityStaphylococcus aureusAntimicrobialMinimum inhibitory concentrationPyridineBacteriaStereochemistryNuclear chemistryMedicinal chemistryBiochemistryOrganic chemistryBiologyCatalysisGeneticsMetal complexes synthesis and propertiesAdvanced biosensing and bioanalysis techniquesAntimicrobial agents and applications