Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior
Claudia M. Di Gesù, Lisa M. Matz, Ian J. Bolding, Robert Fultz, Kristi L. Hoffman, Antonella Marino, Joseph F. Petrosino, Shelly A. Buffington
Abstract
social deficits. L. reuteri exerts a sexually dimorphic impact on gut microbiota configuration, increasing discriminant taxa between female cohorts. Collectively, these results show multigenerational impacts of HFD-induced dysbiosis in the maternal lineage and highlight the potential of maternal microbiome-targeted interventions for neurodevelopmental disorders.
Topics & Concepts
DysbiosisOffspringBiologyGut floraMicrobiomePregnancyPhysiologyGeneticsImmunologyGut microbiota and healthNeuroendocrine regulation and behaviorTryptophan and brain disorders