Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma
Yiwei Wang, Xiaochen Xie, Shu Li, Dongyong Zhang, Heyu Zheng, Min Zhang, Zhong Zhang
Abstract
experiments showed that silencing RIOK1 inhibited the proliferation, migration, and invasion of glioma cell lines by suppressing AKT and c-Myc expression. These results indicate that the RIOK1-AKT1 axis could play an important role in GBM progression.
Topics & Concepts
AKT1GliomaProtein kinase BGene silencingCancer researchDownregulation and upregulationPhenotypeMedicineSignal transductionBiologyGeneCell biologyGeneticsGlioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolisminterferon and immune responses