Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds
Pei Liu, Hongbo Liu, Qi Sun, Hao Liang, Chunmei Li, Xiaobing Deng, Ying Liu, Luhua Lai
Topics & Concepts
IsatinChemistryProteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)StereochemistryIC502019-20 coronavirus outbreakCoronavirusProtease inhibitor (pharmacology)Enzyme inhibitorEnzymeVirologyBiochemistryCombinatorial chemistryIn vitroVirusOrganic chemistryBiologyViral loadInfectious disease (medical specialty)Antiretroviral therapyOutbreakDiseaseMedicinePathologyComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchSynthesis and biological activity