Development of penipanoid C-inspired 2-benzoyl-1-methyl-2,3-dihydroquinazolin-4(1H)-one derivatives as potential EGFR inhibitors: Synthesis, anticancer evaluation and molecular docking study
K. Veena, M.S. Raghu, K. Yogesh Kumar, Kholood A. Dahlous, Aboud Ahmed Awadh Bahajjaj, G. Mani, Byong‐Hun Jeon, M.K. Prashanth
Topics & Concepts
ChemistryErlotinibLapatinibEGFR inhibitorsIC50T790MCytotoxicityDocking (animal)Epidermal growth factor receptorStereochemistryCombinatorial chemistryLead compoundIn vitroPharmacologyBiochemistryReceptorCancerGefitinibBreast cancerTrastuzumabInternal medicineMedicineNursingQuinazolinone synthesis and applicationsHER2/EGFR in Cancer ResearchSynthesis and Characterization of Heterocyclic Compounds