Factors Influencing Lung Function in Patients with Cystic Fibrosis in Western Romania
Mihaela Dediu, Ioana Mihaiela Ciucă, Monica Marc, Estera Boeriu, Liviu Pop
Abstract
Purpose: The aim of this cross-sectional study was to identify the major factors influencing pulmonary function in CF patients from western side of Romania. Patients and Methods: The study enrolled 51 patients with CF between the ages of 6 and 27.8 years who were monitored at regular visits to the National Cystic Fibrosis Centre and Pius Branzeu County Hospital in Timisoara, Romania, over a period of 2 years. The relationships between lung function, as measured by forced expiratory volume in 1 s (FEV 1 ), with patient age, sex, body mass index (BMI), pancreatic insufficiency (PI), microbial infection, CF-related diabetes (CFRD), CF-associated liver disease (CFLD), and physical activity < 30 min/day, were evaluated by multivariate regression analysis. Results: The results showed that FEV1 was 0.32% higher for each increase in percentile of BMI (95% confidence interval: 0.034– 0.619). In addition, mean FEV 1 was 1.52% lower with every year rise of age. PI and female sex increased the risk of impaired lung function (FEV 1 < 60%). The factors most closely correlated with pulmonary function in pediatric CF patients were current age (negative) and BMI (positive). Conclusion: The findings of this study, in combination with what is known from other studies in CF, suggest that a better nutritional status and infection prophylaxis should be part of a comprehensive clinical management strategy for pediatric CF in Romania. Keywords: cystic fibrosis, pediatric, respiratory disease, cystic fibrosis outcome