Editorial: Antimicrobial resistance in pediatric infectious diseases: antimicrobial resistance, resistance mechanisms and antimicrobial use
Dingle Yu, Yuejie Zheng, Adong Shen, Fann Wu, А. В. Дмитриев, Mogens Kilian, Yonghong Yang
Abstract
Antibiotics are a double-edged sword, and when used, we must avoid not only overuse, but also underuse. In recent years, countries around the world have introduced antibiotic action plans to control antibiotic resistance in bacteria and strictly control the clinical use of antibiotics, which has led to the underuse of clinical antibiotics (WHO;Hsia et al.,2019;Zhang et al.,2019).Yu et al. give a case report about rational use of antibiotics, in which 3 cases of septic arthritis in children caused by S. pyogenes were reported. Once S. pyogenes infection is confirmed, β-lactam antibiotics provide effective treatment, avoiding use of broad-spectrum antibiotics.Underuse is common, as shown by: 1. not using it in time when it should be used; 2. insufficient dosage; 3. insufficient duration. These lead to an increase in bacterial infections and even epidemics. This phenomenon can be confirmed by the outbreak of GAS epidemic in the UK in 2022 (The Lancet,2022;Venkatesan,2023) Further research is necessary to determine the optimal use of these drugs for treating MDR-TB in children.The problem of antimicrobial resistance in children cannot be ignored. We sincerely thank all contributors and reviewers for their support in putting this timely