Self‐Reporting Activated Ester‐Amine Reaction for Enantioselective Multi‐Channel Visual Detection of Chiral Amines
Sheng Wang, Siyu Xie, Hua Zeng, Hongxu Du, Jie Zhang, Xinhua Wan
Abstract
Abstract Chiral recognition is of importance not only in living systems but also in estimating the optical purity of enantiomeric drugs and fabricating advanced materials. Herein we report a novel self‐reporting activated ester‐amine reaction that can provide multi‐channel visual detection of organic amines. It relies on the reaction extent dependent cis‐transoid to cis‐cisoid helical transition of the polyphenylacetylene backbone and the thus triggered fluorescence. Owing to the high selectivity, this visual process can recognize structurally diverse achiral amines and quantitatively check the impurity content. It also shows an outstanding enantioselectivity towards various chiral amines and can be applied to determine enantiomeric composition. The multiple responses in absorption, circular dichroism, photoluminescence, and circularly polarized luminescence make the helical transition of the polymer backbone a potential detection mode for high‐throughput screening of chiral chemicals.