Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1
April Lo, Kristin Holmes, Shriya Kamlapurkar, Filip Mundt, Sitapriya Moorthi, Iris Fung, Shaunt Fereshetian, Jacqueline Watson, Steven A. Carr, Philipp Mertins, Alice H. Berger
Abstract
Both normal and mutant forms of the GTPase RIT1 elicit oncogenic changes similar to mutant RAS in lung epithelial cells.
Topics & Concepts
MutantBiologyWild typeCell biologyCancer researchGTPaseSignal transductionGeneticsGeneProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerMechanisms of cancer metastasis