Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors
Robert K. Leśniak, R. Jeremy Nichols, Marcus D. Schonemann, Jing Zhao, Chandresh R. Gajera, Grace Lam, Khanh Cong Nguyen, J. William Langston, Mark A. Smith, Thomas J. Montine
Topics & Concepts
LRRK2PyrazoleKinaseChemistryDrug discoveryPharmacologyPoint mutationMissense mutationBiochemistryComputational biologyGeneStereochemistryMutationBiologyParkinson's Disease Mechanisms and TreatmentsCholinesterase and Neurodegenerative DiseasesPlant Gene Expression Analysis