Systematic Metabolic Profiling Identifies <i>De Novo</i> Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
Enrico Garbe, Franziska Gerwien, Dominik Driesch, Tina Müller, Bettina Böttcher, Markus H. Gräler, Slavena Vylkova
Abstract
sphingolipid biosynthesis as hypha associated and essential for the filamentation of C. albicans. These findings verified the presence of morphotype-specific metabolic traits in the fungus, which appear connected to the fungal virulence. Furthermore, the here-provided comprehensive description of the fungal metabolome will help to foster future research and lead to a better understanding of fungal physiology.
Topics & Concepts
Candida albicansFilamentationHyphaBacterial adhesinVirulenceMicrobiologyBiologyGeneYeastCorpus albicansFungal proteinBiofilmFungusMulticellular organismGeneticsBacteriaSaccharomyces cerevisiaeBotanyOpticsPhysicsLaserAntifungal resistance and susceptibilityFungal Infections and StudiesPolysaccharides and Plant Cell Walls