HOPX<sup>+</sup> injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia
Amy Stewart, Cecilia R. Schaaf, Jennifer Luff, John Freund, Thomas Becker, Sara Tufts, James Robertson, Liara M. Gonzalez
2021American Journal of Physiology-Gastrointestinal and Liver Physiology29 citationsDOIOpen Access PDF
Abstract
This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, we have evidence that HOPX controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, we use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets.
Topics & Concepts
Stem cellIschemiaIntestinal ischemiaIschemic injuryMedicineCell biologyPathologyBioinformaticsBiologyCancer researchReperfusion injuryInternal medicinePancreatic and Hepatic Oncology ResearchOrgan Transplantation Techniques and OutcomesCongenital Diaphragmatic Hernia Studies