Novel Pt(IV) complexes to overcome multidrug resistance in gastric cancer by targeting P-glycoprotein
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Topics & Concepts
CisplatinChemistryP-glycoproteinOxaliplatinApoptosisMultiple drug resistanceIn vivoPharmacologyEffluxCancer cellCell cultureToxicityDrug resistanceIC50PaclitaxelCytotoxicityIn vitroCancer researchCancerBiochemistryChemotherapyBiologyMedicineInternal medicineAntibioticsGeneticsBiotechnologyOrganic chemistryColorectal cancerMicrobiologyDrug Transport and Resistance MechanismsMetal complexes synthesis and propertiesAsymmetric Hydrogenation and Catalysis