Protective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 Infection
S. Chiba, Peter Halfmann, Masato Hatta, Tadashi Maemura, Shufang Fan, Tammy Armbrust, Olivia M. Swartley, LaTasha K. Crawford, Yoshihiro Kawaoka
Abstract
Severe acute respiratory syndrome coronavirus 2 readily transmits between domestic cats. We found that domestic cats that recover from an initial infection might be protected from reinfection. However, we found long-term persistence of inflammation and other lung lesions after infection, despite a lack of clinical symptoms and limited viral replication in the lungs.
Topics & Concepts
CATSLungMedicineImmunologyImmunityVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusInflammationViral sheddingRespiratory systemViral replicationCoronavirus disease 2019 (COVID-19)VirusPathologyImmune systemInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19