Superresolution light microscopy of the <i>Drosophila</i> histone locus body reveals a core–shell organization associated with expression of replication–dependent histone genes
James P. Kemp, Xiaocui Yang, Zbigniew Domiński, William F. Marzluff, Robert J. Duronio
Abstract
embryos, the HLB disassembles at mitosis and reassembles the core-shell arrangement as histone gene transcription is activated immediately after mitosis. Thus, the core-shell organization is coupled to zygotic histone gene transcription, revealing a link between HLB internal organization and RD histone gene expression.
Topics & Concepts
BiologyHistoneCell biologyLocus (genetics)GeneGeneticsHistone H2AHistone H1RNA Research and SplicingGenomics and Chromatin DynamicsRNA modifications and cancer