Distinct Metabolic Flow in Response to Temperature in Thermotolerant Kluyveromyces marxianus
Tomoyuki Kosaka, Tatsuya Tsuzuno, Seiki Nishida, Sornsiri Pattanakittivorakul, Masayuki Murata, Isamu Miyakawa, Noppon Lertwattanasakul, Savitree Limtong, Mamoru Yamada
Abstract
Kluyveromyces marxianus, a thermotolerant yeast, can grow well at temperatures over 45°C, unlike Kluyveromyces lactis, which belongs to the same genus, or Saccharomyces cerevisiae, which is a closely related yeast. K. marxianus may thus bear an intrinsic mechanism to survive at high temperatures. This study revealed the thermotolerant mechanism of the yeast, including ROS scavenging with NADPH, which is generated by changes in metabolic flow.
Topics & Concepts
Kluyveromyces marxianusKluyveromycesYeastBiochemistryPentose phosphate pathwayReactive oxygen speciesKluyveromyces lactisGlutathioneMetabolic pathwayBiologySaccharomyces cerevisiaeGlycolysisMetabolismChemistryEnzymeMitochondrial Function and PathologyFungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction