Modulation of adenosine A2a receptor oligomerization by receptor activation and PIP2 interactions
Wanling Song, Anna L. Duncan, Mark S.P. Sansom
Abstract
-mediated association interfaces. These results indicate that A2aR oligomerization is responsive to the local membrane lipid environment. This, in turn, suggests a modulatory effect on A2aR whereby a given oligomerization profile favors the dynamic formation of specific supramolecular signaling complexes.
Topics & Concepts
ChemistryReceptorCell biologyBiophysicsModulation (music)G protein-coupled receptorAdenosine receptorBiochemistryBiologyAgonistPhysicsAcousticsReceptor Mechanisms and SignalingAdenosine and Purinergic SignalingNeuropeptides and Animal Physiology