Total synthesis of biseokeaniamides A–C and late-stage electrochemically-enabled peptide analogue synthesis
Yutong Lin, Lara R. Malins
Abstract
-acetal intermediates are engaged with electron-rich aromatics and organometallic reagents to forge modified amino acids and peptides. The value of this late-stage modification method is highlighted by the expedient and divergent production of bioactive peptide analogues, including compounds which exhibit enhanced cytotoxicity relative to the biseokeaniamide natural products.
Topics & Concepts
DecarboxylationLipopeptideElectrochemistryPeptideTotal synthesisChemistryCombinatorial chemistryPeptide synthesisStereochemistryStage (stratigraphy)ElectrodeOrganic chemistryBiochemistryBiologyCatalysisBacteriaGeneticsPhysical chemistryPaleontologyRadical Photochemical ReactionsChemical Synthesis and AnalysisCatalytic C–H Functionalization Methods