Delineating the Mechanism of Action of a Protease Resistant and Salt Tolerant Synthetic Antimicrobial Peptide against <i>Pseudomonas aeruginosa</i>
Gopal Pandit, Tanumoy Sarkar, S. Vignesh, Swapna Debnath, Priyadarshi Satpati, Sunanda Chatterjee
Abstract
was unstructured in water and upon binding to the microbial membrane mimic SDS, suggesting no influence of secondary structure on its antimicrobial potency. Positive charge, optimum hydrophobic-hydrophilic balance, and chain length remained the most important concerns to be addressed while designing small cationic antimicrobial peptides.
Topics & Concepts
AntimicrobialAntimicrobial peptidesPseudomonas aeruginosaPeptideProteaseCathelicidinCytotoxicityChemistryMechanism of actionBiochemistryMicrobiologyBiologyBacteriaIn vitroEnzymeGeneticsAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationAntimicrobial agents and applications