16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis
Danielle L. Tomasello, Jiyoon L. Kim, Yara Khodour, Jasmine M. McCammon, Maya Mitalipova, Rudolf Jaenisch, Anthony H. Futerman, Hazel Sive
Abstract
contributes to changes in neuronal activity and function in 16pdel syndrome through a crucial role for the gene in lipid metabolism.
Topics & Concepts
SynaptogenesisHaploinsufficiencyBiologyZebrafishLipid metabolismSphingolipidCell biologyLipidomicsPremovement neuronal activityCeramideNeuroscienceGeneBiochemistryPhenotypeApoptosisSphingolipid Metabolism and SignalingPancreatic function and diabetesLipid Membrane Structure and Behavior