Copper mediated one-pot synthesis of quinazolinones and exploration of piperazine linked quinazoline derivatives as anti-mycobacterial agents
Satyaveni Malasala, Jitendra Gour, Mohammad Naiyaz Ahmad, Srikanth Gatadi, Manjulika Shukla, Grace Kaul, Arunava Dasgupta, Y.V. Madhavi, Sidharth Chopra, Srinivas Nanduri
Abstract
A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction <italic>via in situ</italic> amine generation using ammonia as the amine source and with the formation of four new C–N bonds in good to excellent yields.
Topics & Concepts
PiperazineChemistryCombinatorial chemistryQuinazolineCopperOrganic chemistryQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsPhenothiazines and Benzothiazines Synthesis and Activities