Site-Specific Oxidation of (sp<sup>3</sup>)C–C(sp<sup>3</sup>)/H Bonds by NaNO<sub>2</sub>/HCl
Jianyou Zhao, Tong Shen, Zhihui Sun, Nengyong Wang, Le Yang, Jintao Wu, Huichao You, Zhong‐Quan Liu
Abstract
A site-specific oxidation of (sp3)C–C(sp3) and (sp3)C–H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.
Topics & Concepts
ChemistryTransition metalArylSolventMoleculeOrganic chemistryCatalysisAlkylCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsChemical Synthesis and Reactions