Amylase degradation enhanced NIR photothermal therapy and fluorescence imaging of bacterial biofilm infections
Lihui Yuwen, Huayu Xiao, Pei Lu, Xiaolong Chen, Jianguang Li, Weijun Xiu, Siyu Gan, Dongliang Yang, Lianhui Wang
Abstract
NSs). Experimental results exhibited that MAPI NSs could accumulate in infected tissues after intravenous injection, degrade in the acidic biofilm microenvironment, and release the loaded ICG for near-infrared (NIR) fluorescence imaging of the infected tissues. Importantly, MAPI NSs could efficiently eliminate MRSA biofilm infections in mice by α-amylase enhanced photothermal therapy. In addition, MAPI NSs exhibited neglectable toxicity towards mice. Given the superior properties of MAPI NSs, the enzyme-degradation enhanced therapeutic strategy presented in this work offers a promising solution for effectively combating biofilm infectious diseases.