Ru(<scp>II</scp>)‐Catalyzed Selective C—H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes
Quanjian Luo, Han‐Chi Wang, Jing Zhang, Jin‐Heng Li, Bo Sun
Abstract
Comprehensive Summary A new, selective Ru(II)‐catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This reaction enables the selective construction of a new C(sp 2 )‐C(sp) bond through C—H activation and C—Br functionalization, and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone and phthalazinone derivatives with a wide substrate scope and high selectivity.
Topics & Concepts
ChemistryAlkynylationCatalysisCombinatorial chemistrySelectivityScope (computer science)Substrate (aquarium)Organic chemistryProgramming languageComputer scienceOceanographyGeologyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsQuinazolinone synthesis and applications